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自1952年,异菸肼(INH)就已广泛用于结核病的预防和治疗.1974年有膀胱癌危险性增加与应用INH 有关的报告,并且于再次研究中进一步明确仅限于女性。也报告用 INH 治疗的878例病人的研究中膀胱癌的危险性上升。用 INH 诱导色氨酸代谢的改变可能与膀胱癌易感性有关,进而影响该药的安全性.然而,美国、加拿大、波多黎各收用 INH 的几千例病人的随访研究,膀胱癌危险性并未显上升。同
Isoniazid (INH) has been used extensively in the prevention and treatment of tuberculosis since 1952. In 1974, there was a report of an increased risk of bladder cancer associated with the use of INH, and further studies were limited to women in further studies. Studies of 878 patients treated with INH also reported an increased risk of bladder cancer. INH induced changes in tryptophan metabolism may be associated with bladder cancer susceptibility, thereby affecting the safety of the drug However, the United States, Canada, Puerto Rico INH thousands of patients with follow-up study, the risk of bladder cancer did not Significantly increased. with