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对140名冠心病人随机分为4组,按规定使用小剂量阿斯匹林及硝苯啶。经观察发现:FxB_2/PGF比值为对照组>ASA组>NiF组>A十N组;用药后NiF、A+N组PAWP较前明显降低,Ci、Co、FS有所增加。结果提示:治疗量的NiF与小剂量ASA合用对TxA_2/PGI_2平衡、改善心功能效应最佳。
140 patients with coronary heart disease were randomly divided into 4 groups, according to the provisions of low-dose aspirin and nifedipine. It was observed that the ratio of FxB_2 / PGF was control group> ASA group> NiF group> A10N group. The PAWP of NiF and A + N group was significantly lower than before, and Ci, Co, FS increased. The results suggest that the combination therapy of NiF and low-dose ASA can balance TxA 2 / PGI 2 and improve cardiac function.