【摘 要】
：
Cancer phototheranostics involving optical imaging-guided photodynamic therapy (PDT) and photothermal therapy (PTT) is a localized noninvasive approach in treating cancer.Mitochondria-targeted near-infrared (NIR) cyanines are excellent therapeutic photose
【机 构】
：
Engineering Research Center of Molecular & Neuroimaging,Ministry of Education,School of Life Science
论文部分内容阅读
Cancer phototheranostics involving optical imaging-guided photodynamic therapy (PDT) and photothermal therapy (PTT) is a localized noninvasive approach in treating cancer.Mitochondria-targeted near-infrared (NIR) cyanines are excellent therapeutic photosensitizers of cancer.However,most mitochondria-targeted cyanines exist in the form of hydrophobic structures,which in vivo may cause cyanine aggregation during blood circulation,resulting in poor biocompatibility and limited therapeutic efficacy.Therefore,we developed a trade-off strategy by encapsulating mitochondria-targeted cyanines into liposomal bilayers (CyBI7-LPs),which balanced hydrophilicity that favored blood circulation and hydrophobicity that enhanced mitochondria tumor targeting.Moreover,CyBI7-LPs greatly minimized photobleaching of cyanine as self-generated reactive oxygen species (ROS) could rapidly escape from the liposomal bilayer,affording enhanced PTT/PDT efficacy.Bioorthogonal-mediated targeting strategy was further employed to improve uptake of tumor cells by modifying the liposomal surface to generate CyBI7-LPB.The CyBI7-LPB probe produced a tumor-to-background ratio (TBR) of approximately 6.4 at 24 HPI.Guiding by highly sensitive imaging resulted in excellent anti-tumor therapy outcomes using CyBI7-LPB due to the enhanced photothermal and photodynamic effects.This proposed liposomal nanoplatform exhibited a simple and robust approach as an imaging-guided synergistic anti-tumor therapeutic strategy.
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