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目的探讨芪苈强心胶囊对急性心肌梗死(AMI)患者血清脑钠肽(BNP)水平及心功能的影响。方法选择AMI患者96例,随机分为两组各48例,均接受芪苈强心胶囊治疗,常规治疗组予以抗血小板、抗凝、调脂、β受体阻滞剂、血管紧张素转换酶抑制剂、血运重建等规范化治疗;芪苈强心组在常规治疗基础上加用芪苈强心胶囊,1.2g/次,3次/d,随访12周。比较治疗前后两组患者血清BNP、左室射血分数(LVEF)和左室舒张末内径(LVEDd)的变化。结果 AMI患者血清BNP水平明显升高;治疗后,与常规治疗组比较,芪苈强心组患者血清BNP水平下降更明显,LVEDd及LVEF进一步改善,差异有统计学意义(P<0.05)。结论AMI患者在常规治疗基础上联用芪苈强心胶囊,能进一步降低血清BNP水平,改善心衰患者的心功能及预后。
Objective To investigate the effect of Qili Qiangxin Capsule on serum brain natriuretic peptide (BNP) level and cardiac function in patients with acute myocardial infarction (AMI). Methods Ninety-six patients with AMI were randomly divided into two groups of 48 patients, each receiving Qili Qiangxin Capsule. The conventional treatment group was given anti-platelet, anticoagulation, lipid-lowering, β-blockers, angiotensin converting enzyme Inhibitors, revascularization and other standardized treatment; Qiliuqiangxin group on the basis of conventional therapy plus Qili Qiangxin capsule, 1.2g / time, 3 times / d, followed up for 12 weeks. The changes of serum BNP, left ventricular ejection fraction (LVEF) and left ventricular end-diastolic diameter (LVEDd) in two groups before and after treatment were compared. Results Serum levels of BNP were significantly increased in patients with AMI. After treatment, the serum BNP levels were significantly decreased and LVEDd and LVEF were further improved in the patients with Qiliqiangxin (P <0.05) after treatment. Conclusion AMI patients combined with Qili Qiangxin capsule on the basis of routine treatment, can further reduce serum BNP levels, improve heart function and prognosis of patients with heart failure.