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目的 探讨国产加贝酯对急性水肿型胰腺炎的疗效和不良反应。 方法 应用加贝酯和一般常规治疗方法对158例年龄在20-60岁的急性水肿型胰腺炎患者进行多中心、随机、对照临床研究,其中加贝酯组81例,一般常规治疗(对照组)77例。 结果 加贝酯组显效率(74.1％)及总有效率(100％)均高于对照组(41.5％及94.8％),加贝酯组疗效显著优于对照组(P<0.01和P<0.05),且不良反应少而轻,除3例(3.7％)注射局部皮肤发红、疼痛,2例(2.4％)静脉炎,1例皮疹外,未发现肝、肾、心及血液损伤。 结论 国产加贝酯治疗急性胰腺炎起效迅速,疗效肯定,副反应少而轻。对60-80岁的急性胰腺炎患者亦有较好疗效。
Objective To investigate the efficacy and side effects of domestic Gabapentin on acute edematous pancreatitis. Methods A total of 158 patients with acute edematous pancreatitis aged 20-60 years were enrolled in this study. The results of multi-center, randomized, controlled clinical study included Gabapentin group and conventional routine therapy (control group ) 77 cases. Results The effective rate (74.1%) and total effective rate (100%) in the Gabapeptide group were significantly higher than those in the control group (41.5% and 94.8%, respectively), and those in the Gabapelester group were significantly better than those in the control group (P <0.01 and P < ). The adverse reaction was less and less. No liver, kidney, heart and blood damage were found in 3 cases (3.7%) with local skin redness and pain, 2 cases (2.4%) phlebitis and 1 case skin rash. Conclusion Domestic Gabapeptide treatment of acute pancreatitis rapid onset, positive effect, less side effects and light. 60-80 years of age in patients with acute pancreatitis also have a good effect.