论文部分内容阅读
目的研究冠状动脉血流缓慢综合征患者血管内皮功能和细胞间粘附分子1(ICAM-1)和血管细胞粘附分子1(VCAM-1)水平。方法冠状动脉血流速度应用TFC方法评价,慢血流组12例冠状动脉血流缓慢综合征患者,对照组15例正常人,测量和比较两组肱动脉内皮依赖的血流量介导的扩张反应(FMD),酶标记免疫检测法(ELIMA)测量两组患者血浆中ICAM-1和VCAM-1水平。结果冠状动脉血流缓慢综合征患者内皮依赖的血流量介导的扩张反应较对照组显著降低(P<0.05),含服硝酸甘油后肱动脉的内径变化在两组相似;血浆ICAM-1水平在冠状动脉血流缓慢综合征组明显高于对照组(ICAM-1:577±194ng/ml比251±129ng/ml,P<0.01).冠状动脉血流缓慢综合征组的VCAM-1显著高于对照组(VCAM-1∶2105±597ng/ml比818±376ng/ml,P<0.01)。结论冠状动脉血流缓慢综合征患者不仅存在系统性的内皮功能失常亦存在导致内皮功能失常的慢性炎症反应。
Objective To investigate the expression of vascular endothelial cell adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in patients with coronary artery systolic slow syndrome. Methods Coronary artery blood flow velocity was evaluated by TFC method. Twelve patients with slow flow syndrome of coronary artery in the slow flow group and 15 normal persons in the control group were measured and compared. Endothelium-dependent blood flow-mediated dilatation (FMD) and enzyme-linked immunosorbent assay (ELIMA) were used to measure plasma levels of ICAM-1 and VCAM-1 in both groups. Results Endothelium-dependent blood flow-mediated dilatation response was significantly lower in patients with coronary artery disease than in controls (P <0.05). The changes in the diameter of the brachial artery after nitroglycerin administration were similar between the two groups. The levels of plasma ICAM-1 The rate of VCAM-1 was significantly higher in the group of slow coronary syndromes than in the control group (ICAM-1: 577 ± 194 ng / ml vs 251 ± 129 ng / ml, P <0.01) (VCAM-1: 2105 ± 597 ng / ml vs 818 ± 376 ng / ml, P <0.01). Conclusion There is not only systemic endothelial dysfunction but also chronic inflammatory reaction leading to endothelial dysfunction in patients with coronary artery systolic slow syndrome.