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间充质干细胞(MSCs)具有增殖能力强、分化范围广及低免疫原性等生物学特性，被广泛用于免疫性疾病的研究。同时，越来越多的研究发现在免疫性疾病的发生发展中T淋巴细胞具有重要作用，并证实MSCs可通过直接接触、细胞因子作用等途径影响T淋巴细胞的激活、增殖及亚群比例，继而达到免疫调控、缓解病情的目的。“,”Mesenchymal stem cells have the biological characteristics involving strong proliferation capability,widely distribution and low immunogenicity,which are used in the treatment of the immune diseases.A growing number of studies have found that T lymphocytes play a significant role in the development and progression of autoimmune disease.And MSCs can influence the activation,proliferation and the proportion of subsets of T lymphocytes through the cell-cell contact,cytokine,then achieve the goal of immune regulation,relieve illness.The review summarizes that the immune effect of MSCs on T lymphocytes.