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目的观察健脾清化方治疗耐药幽门螺杆菌(Hp)感染性胃炎脾虚湿热证的临床疗效,以及健脾清化方联合西药补救三联对耐药Hp的根除作用。方法采用随机对照研究,将80例耐药Hp感染性胃炎患者按随机数字表法分为中药组和西药组各40例,中药组予健脾清化方联合补救三联治疗,西药组予标准补救治疗方案治疗,疗程4周。观察2组证候积分、总体疗效以及Hp感染清除率和根除率。结果 2组证候总积分治疗前后比较差异均有统计学意义(P<0.01),治疗后组间差异均具有统计学意义(P<0.01)。2组治疗后组间各证状积分比较,用药4周后胃脘痞胀、主症其他症状、胃脘灼热、恶心呕吐、大便黏滞、伴随其他症状,中药组疗效明显优于西药组(P<0.05)。中药组总有效率94.74%,高于西药组81.08%。中药组耐药Hp清除率为86.84%,根除率为73.68%;西药组对耐药Hp清除率为75.68%,根除率为51.35%。结论健脾清化方联合补救三联对脾虚湿热证耐药HP感染性胃炎有较好的疗效,对根除耐药Hp具有良好的作用。
Objective To observe the clinical efficacy of Jianpi Qinghua Decoction in treating Helicobacter pylori-resistant gastritis with Spleen Deficiency and Damp-heat Syndrome, and to eradication of drug-resistant Hp by Jianpi Qinghua Decoction combined with western remedy. Methods A randomized controlled study was conducted in which 80 cases of Hp-infected gastritis were divided into 40 cases in traditional Chinese medicine group and western medicine group according to random number table method. The traditional Chinese medicine group was given “Jianpi Qinghua Decoction” Treatment regimen, treatment for 4 weeks. Two groups of syndromes were observed, the overall efficacy and Hp infection clearance and eradication rate. Results The total score of the two groups was significantly different before and after treatment (P <0.01). There was significant difference between the two groups after treatment (P <0.01). The scores of syndromes in the two groups after treatment showed that the curative effect of the traditional Chinese medicine group was significantly better than that of the Western medicine group (P <0.05) after 4 weeks of treatment. The symptoms of the main symptom, epigastric heartburn, nausea and vomiting, visceral stool, P <0.05). The total effective rate of TCM group was 94.74%, higher than 81.08% of western medicine group. The drug-resistant Hp clearance rate was 86.84% and the eradication rate was 73.68%. The drug-resistant Hp clearance rate was 75.68% and the eradication rate was 51.35% in the western medicine group. Conclusions Jianpi Qinghua Decoction combined with remedial triple therapy has good curative effect on HP-infected gastritis with spleen deficiency damp-heat syndrome and has a good effect on eradicating drug-resistant Hp.