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目的探讨血清胱抑素C水平变化与妊娠期高血压疾病的关系,评估胱抑素C对妊娠期高血压疾病诊断价值。方法随机抽取2011年7月-2012年1月湖北省妇幼保健院住院分娩孕产妇为研究对象。收集妊娠期高血压疾病253例,同时选择无妊娠合并症与并发症健康孕妇250例作为对照组,检测孕妇血清胱抑素C(CysC)、β2微球蛋白(β2-MG)、尿素氮(BUN)、尿酸(UA)及C-反应蛋白(CRP)水平进行比较。结果妊娠期高血压疾病组各项指标水平均高于对照组,且差异有统计学意义(P<0.05)。妊娠期高血压疾病组血清CysC与β2-MG、UA水平呈正相关,与β2-MG相关性最强(r=0.586,P<0.05)。CysC、β2-MG、UA与BUN的ROC曲线下面积(AUC)分别为0.862(95%CI为0.734~0.923)、0.763(95%CI为0.652~0.822)、0.742(95%CI为0.527~0.718)和0.704(95%CI为0.421~0.615),差异有统计学意义(P<0.01)。结论胱抑素C在评价妊娠期高血压疾病早期肾损害中起重要作用。
Objective To investigate the relationship between serum cystatin C level and hypertensive disorder complicating pregnancy, and to evaluate the value of cystatin C in the diagnosis of hypertensive disorder complicating pregnancy. Methods From July 2011 to January 2012, maternal and childbirth in Hubei Maternal and Child Health Hospital was selected as the research object. Serum levels of cystatin C (CysC), β2-microglobulin (β2-MG) and blood urea nitrogen (BUN) in pregnant women were measured by using 253 pregnant women without pregnancy complications and complications as control group. BUN), uric acid (UA) and C-reactive protein (CRP) levels were compared. Results The indexes of gestational hypertension group were all higher than those of the control group, and the difference was statistically significant (P <0.05). Serum CysC was positively correlated with β2-MG and UA in gestational hypertension group, and had the highest correlation with β2-MG (r = 0.586, P <0.05). The area under the ROC curve for CysC, β2-MG, UA and BUN were 0.862 (95% CI 0.734-0.923), 0.763 (95% CI 0.652-0.822) and 0.742 (95% CI 0.527-0.718) ) And 0.704 (95% CI 0.421 ~ 0.615), the difference was statistically significant (P <0.01). Conclusion Cystatin C plays an important role in the assessment of early renal damage in hypertensive disorders of pregnancy.