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槟榔含的槟榔碱是一种胆碱能物质和挥发性生物碱,槟榔碱可增加脑的乙酰胆碱含量。作者遇到2例支气管哮喘患者因咀嚼槟榔即刻诱发哮喘急性发作,由于世界上约有2亿人口有咀嚼槟榔的嗜好,遂对此进行研究。方法①体外研究:测定槟榔碱和乙酰甲胆碱对离体豚鼠气管、肺组织和人支气管条的作用和效能。②槟榔碱和乙酰甲胆碱支气管激发试验:对7例20～40岁轻度哮喘患者(4女、3男),6例22～40岁非哮喘者(4男、2女),按双盲法进行槟榔碱和乙酰甲胆碱支气管激发试验。试验前6周无嚼槟榔、抽烟或呼吸道感染。吸入溶液递增浓度乙酰甲胆碱为1～32mg/ml,槟榔碱为1.2～38.4mg/ml。③咀嚼槟榔支气管激发试验:4例50～60岁稳定期哮喘患者,咀
Areca nut areca palmitate is a substance and volatile alkaloids, arecoline can increase brain acetylcholine content. The authors encountered two cases of bronchial asthma due to betel nut chewing immediately induced an acute attack of asthma, as the world’s about 200 million people betel nut chewing habit, then the study. Methods ① In vitro studies: The effects and the potency of arecoline and methacholine on the bronchial, pulmonary and bronchial strips of guinea pigs were measured. ② arecoline and methacholine bronchial provocation test: 7 cases of mild asthma (4 female, 3 male) and 6 non-asthma (4 male, 2 female) aged from 20 to 40 years old were treated with double Blind Ischemic and methacholine bronchial provocation test. 6 months before the test no betel nut, smoking or respiratory tract infection. Increasing concentration of inhalation solution of methacholine is 1 ~ 32mg / ml, arecoline is 1.2 ~ 38.4mg / ml. ③ Chewing betel nut bronchial provocation test: 4 cases of 50 to 60-year-old stable asthma patients, Tsui