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探讨危重症患儿血浆纤维连接蛋白（Ｆｎ）的变化特点及其意义。测定７５名危重患儿Ｆｎ含量。结果显示：其值（１６０．４２±７８．１８ｍｇ／Ｌ）明显下降，与正常儿童的Ｆｎ含量（２５９．３０±３４．６８ｍｇ／Ｌ）相比有显著性差异（ｔ＝５．１１１，Ｐ＜０．０１）；呼吸衰竭、全身感染和中枢神经系统疾病时Ｆｎ均有降低；另外，２２例门诊或中度呼吸道感染的患儿Ｆｎ与正常儿童相比无显著性差异（ｔ＝１．８７１，Ｐ＞０．０５），而与危重症患儿相比差异有显著性（ｔ＝５．４０９，Ｐ＜０．０１）；严重呼吸衰竭需机械通气患儿Ｆｎ含量比呼吸衰竭不需机械通气患儿Ｆｎ降低更明显；而感染性休克患儿Ｆｎ比未合并休克患儿的Ｆｎ减低更明显。所以，小儿危重症时Ｆｎ降低主要与疾病的严重程度有关，Ｆｎ若持续降低，则提示预后不良，Ｆｎ可作为判定疾病严重程度和病情转归的指标之一，也可作为临床Ｆｎ替代治疗的一个指征
To investigate the changes of plasma fibronectin (Fn) in critically ill children and its significance. Determination of Fn content in 75 critically ill children. The results showed that the value of (160.42 ± 78.18 mg / L) was significantly lower than that of normal children (259.30 ± 34.68 mg / L) (t = 5.111, P <0.01). Fn in respiratory failure, systemic infection and central nervous system diseases decreased. In addition, there was no significant difference in Fn between the two groups (t = 1. 871, P> 0.05), while there was a significant difference compared with those in critically ill children (t = 5.409, P <0.01). The Fn content in children with severe respiratory failure requiring mechanical ventilation was lower than that in respiratory failure Fn in children with mechanical ventilation decreased more obviously; and Fn in children with septic shock than in children without shock Fn decreased more significantly. Therefore, the reduction of Fn in children with critical illness is mainly related to the severity of the disease. If Fn continues to decline, it indicates that the prognosis is poor. Fn may be used as an index to determine the severity of the disease and the prognosis of the disease, and may also be used as a clinical Fn replacement therapy An indication