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研究重组人白介素 2 (rhIL 2 )的抗炎和免疫调节作用。选择小鼠鼠耳肿胀和大鼠足拓肿胀模型研究rhIL 2的抗炎作用 ;选择碳廓清率实验、迟发性变态反应实验研究rhIL 2的免疫调节作用。RhIL 2注射液 ,剂量为 2 0 ,10 ,5,2 .5,1.2 5万u/kg时 ,对小鼠鼠耳肿胀模型有抑制作用 ,其中剂量为 2 .5～ 5万u/kg时 ,抑制率最大 ;剂量为 2 .5万u/kg时 ,对大鼠足拓肿胀模型有显著的抑制作用 ;rhIL 2注射液每日sc用药剂量为 10万u/kg ,连续给药 9d后 ,可以明显增强小鼠单核吞噬细胞功能 ;rhIL 2注射液每日sc用药剂量为 5万u/kg ,连续给药 6d后 ,可明显减轻由免疫抑制剂引起的小鼠迟发性变态反应降低的强度。rhIL 2在一定剂量范围内可以起到抗炎和免疫调节作用
To study the anti-inflammatory and immunomodulatory effects of recombinant human interleukin 2 (rhIL 2). The anti-inflammatory effects of rhIL 2 were investigated by mouse ear swelling and rat foot swelling model. The effects of rhIL 2 immunoregulation were studied by carbon clearance rate assay and delayed-type hypersensitivity test. RhIL 2 injection at doses of 20, 10, 5, 2.5 and 12.5 million u / kg had inhibitory effects on mouse ear swelling model, in which the dose was 2.5-500 u / kg , And the inhibition rate was the highest. When the dose was 25,000 u / kg, the rat model of paw foot swelling was significantly inhibited. The daily dose of rhIL 2 injection was 100 000 u / kg, and after 9 days of continuous administration , Can significantly enhance the function of mouse mononuclear phagocytes; rhIL 2 injection sc daily dose of 50,000 u / kg, continuous administration of 6d, can be significantly reduced by immunosuppressive agents induced delayed allergic reaction Reduced intensity. rhIL 2 can act as anti-inflammatory and immunomodulatory in a range of doses