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目的探讨高功率密度毫米波远位照射和联合放疗的抗瘤效应及可能机制。方法小鼠肝癌种瘤模型分组，观察动物生存期、瘤重及有丝分裂细胞数。 Ａ组为种瘤对照组；Ｂ组为单纯放疗组，全肝 γ－射线照射 ２ Ｇｙ ×６次；Ｃ组为单纯毫米波组，动物背部照射毫米波 ３０分钟× １４次；Ｄ组为综合组，先照射毫米波后 γ－射线放射，剂量同Ｂ组和Ｃ组。结果各组平均生存日分别为１９、２５．８、３１．３和３３．３天（Ｐ＜０．０１）；平均瘤重分别为１，０９、０．５９、０． ２５、０． ２０ ｇ（Ｐ＜０． ０１）；每视野核分裂细胞数分别为 ３２． ２、２２． ６、１６． ２、１５． ４只（Ｐ＜０．０１）。联合组小鼠生存延长率达７５．３％、抑瘤率８１．２％、核分裂抑制率５２．２％。结论高功率密度毫米波对实验小鼠具有良好的远位抗瘤效应，联合放疗效果最好，从而提示两者的协同抗瘤增敏效应。
Objective To investigate the antitumor effect and possible mechanism of high power density millimeterwave remote irradiation and radiotherapy. Methods Mouse liver cancer tumor models were divided into groups to observe the survival, tumor weight and number of mitotic cells. Group A was a tumor-control group; Group B was a radiotherapy group with 2 Gy of whole liver γ-ray irradiation for 6 times; group C was a simple millimeter wave group and a millimeter wave was irradiated for 30 minutes by a back animal × 14 times; Group, the first exposure to millimeter wave γ-ray radiation, the same dose with B and C group. Results The mean survival days were 19,25.8,31.3 and 33.3 days in each group (P <0.01). The mean tumor weights were 1,09,0.59,0. 25,0. 20 g (P <0.01). The number of mitotic cells per field was 32. 2,22. 6,16. 2,15. 4 (P <0.01). The survival rate of mice in combination group was 75.3%, the inhibition rate was 81.2%, and the rate of mitosis was 52.2%. Conclusion The high power density millimeter wave has a good anti-tumor effect in distant mice and the best combined radiotherapy, suggesting the synergistic antitumor and sensitization effect of both.