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目的:探讨葡萄膜炎并发白内障患者术后应用曲安奈德的治疗效果。方法:收集48例葡萄膜炎并发白内障术后患者,按入组编号随机分为观察组与对照组,每组各24例,观察组应用曲安奈德联合泼尼松龙干预治疗,对照组单用泼尼松龙,对比观察两组患者术后视力恢复情况、眼压变化情况、前房炎症反应情况、并发症发生情况,并随访3个月观察复发情况。结果:观察组术后视力恢复情况优于对照组,术后1 d虽无统计学意义(P>0.05),但术后一周及一个月,观察组分别为15例、18例,而对照组为11例、12例,两组比较差异均有统计学意义(P<0.05);两组患者术后眼压较术前均降低,但术后1 d及1周相比差异均无统计学意义(P>0.05);观察组前房炎症反应程度低于对照组,术后1 d及1周两组相比差异均有统计学意义(P<0.05);观察组并发症发生率及复发率分别为20.83%、12.50%,低于对照组的37.50%、25.00%,两组比较差异均有统计学意义(P<0.05)。结论:曲安奈德干预治疗葡萄膜炎并发白内障术后患者效果肯定,患者不仅视力恢复快、前房炎症反应轻,且并发症少、复发率低,临床值得推广应用。
Objective: To investigate the therapeutic effect of triamcinolone acetonide in patients with uveitis complicated with cataract. Methods: Forty-eight patients with uveitis complicated with cataract were enrolled. The patients were randomly divided into observation group and control group according to the group number. Each group had 24 cases. The observation group was treated with triamcinolone acetonide combined with prednisolone. The control group Prednisolone was used to compare the postoperative visual acuity recovery, intraocular pressure changes, anterior chamber inflammatory response and complications in the two groups. The recurrence was observed 3 months after the operation. Results: The postoperative visual acuity recovery in the observation group was superior to that in the control group, although there was no statistical difference on the first postoperative day (P> 0.05), but the observation group was 15 cases and 18 cases one week and one month after the operation, (P <0.05). The postoperative IOP of both groups was lower than that before operation, but there was no significant difference at 1 and 1 week after operation (P> 0.05). The degree of inflammation in the anterior chamber in the observation group was lower than that in the control group, and the difference was statistically significant (P <0.05) on the 1st and 2nd week after operation. The incidence and recurrence of complications in the observation group The rates were 20.83% and 12.50%, respectively, which were lower than those of the control group (37.50% and 25.00%). There was significant difference between the two groups (P <0.05). Conclusion: The effect of triamcinolone acetonide in the treatment of uveitis complicated with cataract surgery is affirmed. The patients not only have faster visual acuity, less inflammation in the anterior chamber, less complications and low recurrence rate, it is worth popularizing and applying clinically.