The emerging role of autophagic-lysosomal dysfunction in Gaucher disease and Parkinson＇s disease

• 作 者: Kerri J.Kinghorn Amir M.Asghar
• 机 构: InstituteofHealthyAgeingandDepartmentofGenetics,InstituteofNeurology,DepartmentofBasicandClinicalNeu
• 出 处: 中国神经再生研究：英文版
• 发表日期: 2017年3期
• 关键词: 功能障碍 溶酶体 帕金森氏病 自噬 Α-突触核蛋白 神经退行性疾病 功能缺陷 基因突变 Gaucher disease Parkinson＇s disease

Gaucher disease(GD),the commonest lysosomal storage disorder,results from the lack or functional deficiency of glucocerebrosidase(GCase) secondary to mutations in the GBA1 gene.There is an established association between GBA1 mutations and Parkinson's