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AIM:To investigate the clinical characteristics of pancreatic malignant melanoma.METHODS:Here we report a case of pancreatic malignant melanoma and present a meta-analysis of pancreatic melanoma based on data from well-documented case reports.RESULTS:A 32-year-old male presented with abdominal pain and jaundice.Computed tomography showed a non-discrete mass in the head of the pancreas.A pancreatoduodenectomy was performed.Histology revealed pancreatic malignant melanoma.Immunostaining showed that the neoplastic cells were positive for Melan A and S100,and that they expressed HMB-45.A review of 13 publications reporting 15 cases identified main clinical symptoms as abdominal pain(nine cases)and jaundice(three cases).Nine patients had a historyof extra-abdominal malignant melanoma.The overall median survival time was 10 mo.CONCLUSION:Pancreatic malignant melanoma is not typified by any special clinical presentation.The diagnosis depends on biopsy or specimen histology.Surgical resection remains the best treatment choice.
AIM: To investigate the clinical characteristics of pancreatic malignant melanoma. METHODS: Here we report a case of pancreatic malignant melanoma and present a meta-analysis of pancreatic melanoma based on data from well-documented case reports .RESULTS: A 32-year-old male presented with abdominal pain and jaundice. Computed tomography showed a non-discrete mass in the head of the pancreas. A pancreatoduodenectomy was performed. Histology revealed pancreatic malignant melanoma. Immunostaining showed that the neoplastic cells were positive for Melan A and S100, and that They identified HMB-45.A review of 13 publications reporting 15 cases identified major clinical symptoms as abdominal pain (nine cases) and jaundice (three cases) .Nine patients had a history of extra-abdominal malignancy melanoma. The overall median survival time was 10 mo.CONCLUSION: Pancreatic malignant melanoma is not typified by any special clinical presentation. The diagnosis depends on biopsy or specimen histology .urgical resection remains the best treatment choice.