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目的 分离并分析与我国Down′s综合征 (DS)发生相关的环境因子及影响因素。方法 用传统的流行病学病例 -对照方法收集资料 ,再进行单因素和多因素的非条件性Logistic回归分析。结果 母亲自然流产史、长期接触电脑等辐射、长期被动吸烟、饮酒、使用多量味精、孕前服用避孕药及抗感染药是DS发生的危险因素。在父亲方面的危险因素有吸烟、饮酒、味精和肝炎病史。结论 这些因素与DS存在一定的相关性。进一步研究细胞遗传学和分子生物学有助于明确其作用机制。
Objective To separate and analyze environmental factors and influencing factors related to the occurrence of Down’s Syndrome (DS) in China. Methods Traditional epidemiological case-control methods were used to collect data, followed by univariate and multivariate unconditional logistic regression analysis. Results Mother spontaneous abortion history, long-term exposure to computer and other radiation, long-term passive smoking, alcohol consumption, the use of large amounts of MSG, taking pre-pregnancy contraceptives and anti-infectives are DS risk factors. The risk factors for fathers include smoking, alcohol consumption, MSG and hepatitis history. Conclusion These factors have some relevance with DS. Further research on cytogenetics and molecular biology will help clarify its mechanism of action.