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一般认为,氟康唑(FCZ)仅能抑制真菌生长。但近期发现,FCZ可杀菌。本文作者研究了在延长培养时间下影响FCZ对白念珠菌(CA)活力的因素。实验采用两种抑制增殖的培养基(蒸馏水和去金属离子的RPMI1640),将CA培养7天后分别检测FCZ敏感株和耐药株对FCZ的敏感性及菌的电镜改变。结果:①CA在抑制增殖培养基中孵育7天后加入1.0μg/
It is generally accepted that fluconazole (FCZ) inhibits fungal growth only. But recently found, FCZ sterilization. The authors studied the factors that affect the viability of Candida albicans (CA) in FCZ with extended incubation time. Two kinds of media (RPMI1640 of distilled water and demethylation) were used in this experiment. The sensitivity of FCZ-sensitive and resistant strains to FCZ and the change of electron microscopy of bacteria were tested after 7 days of CA culture. Results: ①CA in proliferation inhibition medium for 7 days after adding 1.0μg /