结肠直肠的良性成纤维细胞性息肉

• 作 者: Kalof A.N. Pritt B. Cooper K. H. Blaszyk 赵菊辉
• 机 构: Department of Pathology University of Vermont College of Medicine 89 Beaumont Avenue Burlington VT
• 出 处: 世界核心医学期刊文摘(胃肠病学分册)
• 发表日期: 2006年02期
• 关键词: 结肠直肠 成纤维细胞 超微结构 黏膜损伤 免疫组化法 组织病理学 间叶细胞 临床过程 病理学家 临床病理学特征

Goals: We present the clinicopathologic features, endoscopic appearance, and ultrastructure of a newly described mesenchymal polyp of the colorectum, termed benign fibroblastic polyp. Study: A total of 4 cases from our institution are analyzed using routine histopathology, immunohistochemistry, and electron microscopy, and compared with the original series of 14 cases previously described in the pathology literature. Results: Benign fibroblastic polyps appear endoscopically throughout the colorectum as submucosal lesions with a hyperplastic surface component. These lesions are histologically and ultrastructurally distinct, but overlap with other mesenchymal polyps warrants additional immunohistochemical studies for definitive classification. Conclusions: Benign fibroblastic polyps of the colorectum comprise a recently described distinct entity of mesenchymal polyps that appear to follow an indolent clinical course. Their etiology is uncertain but may be linked to an exuberant tissue response following mucosal injury. Gastroenterologists should be aware of this new entity that will be increasingly diagnosed by pathologists.

Goals: We present the clinicopathologic features, endoscopic appearance, and ultrastructure of a newly described mesenchymal polyp of the colorectum, termed benign fibroblastic polyp. Study: A total of 4 cases from our institution are analyzed using routine histopathology, immunohistochemistry, and electron microscopy, and compared with the original series of 14 cases previously described in the pathology literature. Results: Benign fibroblastic polyps appear endoscopically throughout the colorectum as submucosal lesions with a hyperplastic surface component. These lesions are histologically and ultrastructurally distinct but but with other mesenchymal polyps warrants additional immunohistochemical studies for definitive classification. Conclusions: Benign fibroblastic polyps of the colorectum include a recently described distinct entity of mesenchymal polyps that appear to follow an indolent clinical course. Their etiology is uncertain but may be linked to an exuberant tissue re sponse following mucosal injury. Gastroenterologists should be aware of this new entity that will be increasingly established by pathologists.