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目的解析植物药淫羊藿中2种黄酮类化合物的分子结构。方法利用核磁共振波谱(NMR)解析化合物分子结构,利用一维谱1 H-NMR、13C-NMR和DEPT联合推断出氢与碳的原子个数与类型,并初步确定分子中部分官能团及结构片段,继而由二维谱HSQC确定碳氢直接相关关系、1 H-1 H COSY确定氢氢相关及二者结合进一步推断结构片段。最后通过二维碳氢长程相关谱HMBC拼接结构单元得到化合物的分子结构。结果与结论通过NMR波谱分析确定淫羊藿中2种黄酮类化合物为脱水淫羊藿素(Anhydroicaritin,1)和宝藿苷Ⅱ(Ikarisoside A,2)。
Objective To analyze the molecular structure of two flavonoids in Herba Epimedii. Methods The molecular structures of compounds were analyzed by nuclear magnetic resonance (NMR). The number and type of atoms of hydrogen and carbon were extrapolated by 1 H-NMR, 13C-NMR and DEPT, and some functional groups and structural fragments , Followed by two-dimensional spectrum HSQC to determine the direct correlation between hydrocarbons, hydrogen and hydrogen 1 H-1 H COZY correlation and the combination of both to further infer the structure fragment. Finally, the molecular structure of the compound was obtained by splicing the structural unit with two-dimensional hydrocarbon long-range correlation spectroscopy (HMBC). RESULTS AND CONCLUSION The two flavonoids of Epimedium were identified as Anhydroicaritin (I) and Ikarisoside A (2) by NMR spectral analysis.