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目的探讨单磷酸阿糖腺苷联合丙种球蛋白治疗小儿重症手足口病的临床效果。方法选取2013年3月至2015年3月间我院收治的小儿重症手足口病患者140例,随机均分为两组,对照组采取单磷酸阿糖腺苷治疗,观察组采用单磷酸阿糖腺苷联合丙种球蛋白治疗,比较两组患儿的治疗效果。结果观察组的体温恢复时间、神经系统恢复时间均显著短于对照组(P<0.05)。观察组的皮疹治疗总有效率为85.71%,显著高于对照组的65.71%(P<0.05);观察组的临床总有效率为91.43%,显著高于对照组的57.57%(P<0.05)。结论单磷酸阿糖腺苷联合丙种球蛋白治疗小儿重症手口足病的临床疗效显著,值得临床推广使用。
Objective To investigate the clinical effect of adenosine monophosphate combined with gamma globulin in the treatment of severe hand-foot-mouth disease in children. Methods 140 cases of pediatric severe hand-foot-mouth disease admitted to our hospital from March 2013 to March 2015 were randomly divided into two groups. The control group was treated with vidarabine monophosphate. The observation group was treated with monophosphate arabinose Adenosine combined with gamma globulin treatment, the treatment of children with two groups were compared. Results The body temperature recovery time and nervous system recovery time in the observation group were significantly shorter than those in the control group (P <0.05). The total effective rate of the observation group was 85.71%, which was significantly higher than that of the control group (65.71%, P <0.05). The total effective rate of the observation group was 91.43%, significantly higher than that of the control group (57.57%, P <0.05) . Conclusions The combination of vidarabine monophosphate and gamma globulin in the treatment of pediatric severe hand foot and foot disease is significant and worthy of clinical application.