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目的:分析与椎动脉迂曲程度相关的危险因素，探讨椎动脉迂曲的发生机制。方法:对华中科技大学同济医学院附属协和医院神经外科自2016年10月至2017年10月收治并行头颈部磁共振血管成像(MRA)检查的患者，运用图像存储与传输系统(PACS)测量并计算椎动脉迂曲程度。比较不同年龄段患者椎动脉迂曲程度的差异。应用相关性检验分析患者椎动脉迂曲程度和临床资料、生化水平的相关性，多因素线性回归分析确定患者椎动脉迂曲程度的独立危险因素。结果:患者椎动脉迂曲程度为5.1%~72.6%。40~49岁患者左、右侧椎动脉迂曲程度均高于20~29岁、30~39岁患者，差异均有统计学意义(n P<0.05)。相关性分析显示，患者右侧椎动脉迂曲程度与年龄、甘油三酯水平均呈正相关关系(n r=0.232，n P=0.000；n r=0.172，n P=0.004)，患者左侧椎动脉迂曲程度与甘油三酯水平呈正相关关系(n r=0.123，n P=0.043)。多因素线性回归分析显示，年龄、甘油三酯水平为患者右侧椎动脉迂曲程度的独立危险因素(n 95%CI：0.059~0.194，n P=0.000；n 95%CI：0.173~1.942，n P=0.019)，甘油三酯水平为患者左侧椎动脉迂曲程度的独立危险因素(n 95%CI：0.041~2.559，n P=0.043)。n 结论:椎动脉迂曲存在先天性发育相关因素，部分后天因素如甘油三酯水平也可能促进其发展。“,”Objective:To analyze the related risk factors for vertebral artery tortuosity, and explore the mechanism of vertebral artery tortuosity.Methods:Two hundred and eighty-two patients accepted head/neck and MR angiography in our hospital from October 2016 to October 2017 were selected. The tortuosity degrees of vertebral artery were measured and calculated by PACS system. The differences of tortuosity degrees of vertebral arteries in different age groups were compared. Correlation analysis was performed to determine the correlation between vertebral artery tortuosity and both clinical data and and biochemical levels, and multivariate linear regression analysis was performed to determine the independent risk factors for vertebral artery tortuosity.Results:The tortuosity degrees of the left and right vertebral arteries in these patients ranged from 5.1% to 72.6%. The tortuosity degrees of vertebral arteries in patients aged 40-49 years were significantly higher than those in patients aged 20-29 years and 30-39 years (n P<0.05). Correlation analysis showed that the tortuosity degree of the right vertebral artery was positively correlated with age and triglyceride level (n r=0.232, n P=0.000; n r=0.172, n P=0.004); the tortuosity degree of the left vertebral artery was positively correlated with triglyceride level (n r=0.123, n P=0.043). Multivariate regression analysis showed that age (n 95%CI: 0.059-0.194, n P=0.000) and triglyceride level (n 95%CI: 0.173-1.942, n P=0.019) were independent risk factors for right vertebral artery tortuosity. Triglyceride level (n 95%CI: 0.041-2.559, n P=0.043) was independent risk factor for left vertebral artery tortuosity.n Conclusion:There are congenital developmental factors associated with vertebral artery tortuosity; some nurture factor, as triglyceride level, may promote its development.