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自本世纪初Anichkov的家兔胆固醇饲喂实验以来,膳食和血清胆固醇水平之间的关系一直为科学界所注意。最近,McNamara总结了过去30年发表的68份临床研究资料,发现结果相当一致:膳食胆固醇每增加100mg,血清胆固醇平均每分升增加2.3mg。这与Hegsted和Keys公式计算的每分升增加9.6和6.8mg相差甚大。Connor等的研究发现每日膳食胆固醇摄入增至400～500mg时,血清胆固醇随之增高;摄入量再增加,血清胆固醇增高甚微。这些结果表明,随着膳食胆固醇量增加,胆固醇吸收率降低,个体差异是影响胆固醇吸收率的一个重要调节因素。胆固醇摄入
The relationship between diet and serum cholesterol levels has been of concern to the scientific community since Anichkov’s rabbit cholesterol feeding experiments of the early 2000s. Recently, McNamara summarized 68 clinical studies published in the past 30 years and found that the results were quite consistent: serum cholesterol increased by an average of 2.3 mg / dL for every 100 mg increase in dietary cholesterol. This is a significant difference from the 9.6 and 6.8 mg increments per minute for the Hegsted and Keys formulas. Connor and other studies found that daily dietary cholesterol intake increased to 400 ~ 500mg, then increased serum cholesterol; increased intake, serum cholesterol increased slightly. These results show that as dietary cholesterol levels increase, cholesterol absorption decreases, and individual differences are an important mediator of cholesterol absorption. Cholesterol intake