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目的:观察三维适形放疗联合EP方案治疗小细胞肺癌(SCLC)的近期疗效及耐受性。方法:31例SCLC患者均接受三维适形放疗,1次/d,1.8～2Gy/次,5次/周,共28～31次,总剂量50.4～62Gy。照射野包括原发病灶和转移淋巴结及邻近一站淋巴引流区。同步行EP方案化疗。结果:31例患者全部完成治疗计划,CR和PR分别为25.8%(8/31)和45.2%(14/31)。生存质量较前改善。最主要的毒副反应为白细胞及血小板降低,但均可耐受。结论:三维适形放疗联合EP方案治疗SCLC近期疗效较好,毒副反应能为大多数患者耐受。
Objective: To observe the short-term efficacy and tolerability of three-dimensional conformal radiotherapy combined with EP regimen in the treatment of small cell lung cancer (SCLC). Methods: Thirty-one patients with SCLC underwent three-dimensional conformal radiotherapy (once / d, 1.8-2 Gy / time, 5 times / week for 28-31 times) with a total dose of 50.4-62Gy. Radiation field, including primary lesions and metastatic lymph nodes and lymph nodes adjacent to a station drainage area. Synchronous line EP regimen chemotherapy. Results: All 31 patients completed the treatment plan. The CR and PR were 25.8% (8/31) and 45.2% (14/31) respectively. Quality of life improved earlier. The main side effects of leukopenia and thrombocytopenia, but can be tolerated. Conclusion: Three-dimensional conformal radiotherapy combined with EP regimen in the treatment of SCLC has good curative effect in the near future. Toxic side effects can be tolerated in most patients.