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蛇毒中含有多种具有药理作用的多肽及蛋白质,三指蛋白属于其蛋白家族中的一种。三指蛋白止痛无成瘾性,无依赖性,用量少,镇痛作用时间长。为揭示其镇痛机制,从而开发出选择性高、安全性好、副作用小的镇痛药,本文综述了三指蛋白及其镇痛作用的研究进展,以期为相关研究提供参考依据。
Snake venom contains a variety of pharmacological peptides and proteins, three-finger protein belongs to one of its protein family. Three-finger protein analgesic addiction, no dependence, less dosage, analgesic effect of a long time. In order to reveal its analgesic mechanism and develop analgesics with high selectivity, good safety and little side effects, this review summarizes the research progress of the three-finger protein and its analgesic effects in order to provide a reference for the related research.