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用Ｌ－精氨酸及精氨酸－甘氦酸－天冬氨酸即ＲＧＤ序列的短肽精氨酸－甘氨酸－天冬氨酸－苯乙酰胺对正常血压及原发性高血压大鼠离体动脉血管的舒张作用进行了研究。结果发现：Ｌ－精氨酸和精氨酸－甘氨酸－天冬氨酸－苯乙酰胺对于两种动物的血管平滑肌均有程度不等的舒张作用，且该舒张作用显示出剂量依赖性和内皮依赖性。药效动力学分析表明，Ｌ－精氨酸和精氨酸－甘氨酸－天冬氨酸－苯乙酰胺舒张血管的半数有效浓度分别为１０－７和１０－６ｍｏｌ／Ｌ，二者Ａｃ－ＲＧＤ－ＰＥＡ最大舒张效应对于不同处置的不同动物约为４～２０％左右。实验结果提示Ｌ－精氨酸及其衍生物对于血压的调节及高血压的治疗有一定的作用。
Using arginine-glycine-aspartic acid-phenylacetamide, a short peptide of L-arginine and arginine-glycine-aspartic acid, ie RGD sequence, in normotensive and essential hypertensive rats Diastolic effects of isolated arterial blood vessels were studied. As a result, it was found that L-arginine and arginine-glycine-aspartic acid-phenylacetamide exhibited varying degrees of diastolic effects on vascular smooth muscle of both animals and that the diastolic action showed a dose-dependent and endothelial Dependency. Pharmacodynamic analysis showed that the half effective concentrations of L-arginine and arginine-glycine-aspartic acid-phenylacetamide diastolic blood vessels were 10-7 and 10-6 mol / L, respectively. Both Ac-RGD The maximum diastolic effect of PEA was about 4-20% for different animals treated differently. The experimental results suggest that L-arginine and its derivatives play a role in the regulation of blood pressure and the treatment of hypertension.