Sonic hedgehog elevates N-myc gene expression in neural stem cells

• 出 处: Neural Regeneration Research
• 发表日期: 2012年22期
• 关键词: hedgehog sonic downstream progenitor minute inverted expressing secreted Neuron

Proliferation of neural stem cells is regulated by the secreted signaling molecule sonic hedgehog. In this study, neural stem cells were infected with recombinant adeno-associated virus expressing sonic hedgehog-N-enhanced green fluorescent protein. The results showed that over expression of sonic hedgehog in neural stem cells induced the increased expression of Gli1 and N-myc, a target gene of sonic hedgehog. These findings suggest that N-myc is a direct downstream target of the sonic hedgehog signal pathway in neural stem cells. Sonic hedgehog and N-myc are important mediators of sonic hedgehog-induced proliferation of neural stem cells.

Proliferation of neural stem cells is regulated by the secreted signaling molecule sonic hedgehog. In this study, neural stem cells were infected with recombinant adeno-associated virus expressing sonic hedgehog-N-enhanced green fluorescent protein. The results showed that over expression of sonic hedgehog in neural stem cells induced the increased expression of Gli and N-myc, a target gene of sonic hedgehog. These findings suggest that N-myc is a direct downstream target of the sonic hedgehog signaling pathway in neural stem cells. Sonic hedgehog and N- myc are important mediators of sonic hedgehog-induced proliferation of neural stem cells.