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目前,市售的乙型肝炎(HB)疫苗价格昂贵,促使人们研究通过不同注射途径接种低剂量疫苗的免疫原性。一些疫苗(如狂犬病疫苗)已有效地进行皮内(ID)注射。ID注射1/10标准剂量的HB疫苗,可获得与肌肉(IM)注射标准剂量HB疫苗相同的血清阳转率。有4篇文献报告了对成人ID注射美国批准的HB疫苗的结果,但试验对象均较少(<25人)。免疫原性使用ID注射的4项研究中,剂量和接种程序各不相同,但最终的血清阳转率与IM注射足量疫苗相似:用放射免疫法测出,86～100%的接种者的抗-HBs滴度
Currently, commercially available hepatitis B (HB) vaccines are expensive and have led to the study of the immunogenicity of vaccinating low doses by different routes of injection. Some vaccines, such as rabies vaccines, have been effectively injected intradermally (ID). ID injection of a 1/10 standard dose of HB vaccine resulted in the same seroconversion rate as the standard dose of HB vaccine injected into the muscle (IM). Four articles reported results of adult-ID injections of U.S.-approved HB vaccines, but fewer subjects (<25). Immunogenicity In the four studies using ID injections, the dose and vaccination procedures differed but the final seroconversion rate was similar to the IM-injected full-dose vaccine: 86-100% of those vaccinated Anti-HBs titer