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目的 研究血清可溶性白细胞介素2受体(sIL-2R)和肿瘤坏死因子(TNF-α)水平在老年人喉癌中的临床意义。方法 应用单克隆、多克隆双抗体夹心ELISA检测了27例老年喉鳞癌患者sIL-2R和TNF-α水平。结果 老年喉癌患者sIL-2R水平较良性组或正常人显著升高(P<0.001),与喉癌淋巴结转移、临床分型亦密切相关;喉癌患者TNF-α水下只有Ⅳ期显著高于良性组或正常人(P<0.05)。结论 血清sIL-2R水下检测可做为老年人喉癌诊断的一项辅助指标,并有助于了解喉癌的大小,临床进程及生物学行为(如淋巴结转移等);TNF-α在介导喉癌的恶病质方面起重要作用。
Objective To investigate the clinical significance of serum soluble interleukin 2 receptor (sIL-2R) and tumor necrosis factor (TNF-α) levels in the elderly with laryngeal cancer. Methods Monoclonal and polyclonal antibody sandwich ELISA was used to detect the levels of sIL-2R and TNF-α in 27 elderly patients with laryngeal squamous cell carcinoma. Results The level of sIL-2R in elderly patients with laryngeal cancer was significantly higher than that in benign group or normal group (P <0.001), which was also closely related to the lymph node metastasis and clinical classification of laryngeal cancer. The level of TNF- In benign group or normal group (P <0.05). Conclusion The detection of sIL-2R in serum can be used as an auxiliary index for the diagnosis of laryngeal cancer in the elderly and help to understand the size, clinical process and biological behavior of laryngeal cancer (such as lymph node metastasis) Guide the cachexia of laryngeal cancer plays an important role.