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由于种种原因使得老年人对流感疫苗的免疫应答低于年轻人.一种可能提高老年人对流感疫苗免疫应答的方法是添加强的免疫佐剂,如可与流感疫苗合用的MF59就是有希望的新型佐剂.MF59是含有5%V/V鲨烯、0.5%V/V吐温80和0.5%Span85的水包油乳剂.免疫对象为8周龄和18月龄的雌性BALB/c小鼠.作者比较了加或不加MF59的流感疫苗在这两个年龄组小鼠中的免疫情况.以前未感染过流感病毒的小鼠经流感疫苗免疫后,18月龄小鼠的疫苗特异性抗体水平及T淋巴细胞增殖应答明显低于8周龄小鼠.免疫后两组的细胞因子水平和抗体同型分布亦不同.合用MF59的结果表明,未感染过流感病毒的老龄和幼龄小鼠对疫苗的免疫应答均显著提高,其中老龄小鼠的免疫应答水平与仅用疫苗免疫的幼龄小鼠相似.同样,以前感染过流感病毒的老龄小鼠对疫苗
The immune response of older people to flu vaccines is lower than that of young people due to various reasons.One possibility is to increase the immune response to influenza vaccination in the elderly by adding a strong immune adjuvant such as MF59 that can be used with influenza vaccines A novel adjuvant.MF59 is an oil-in-water emulsion containing 5% V / V squalene, 0.5% V / V Tween 80 and 0.5% Span 85. Immunized subjects are female BALB / c mice at 8 and 18 months of age The authors compared the immunization of mice in both age groups with or without the MF59 vaccine Vaccine-specific antibodies to 18-month-old mice immunized with influenza vaccine in mice that had not previously been infected with influenza virus Level and T lymphocyte proliferation response was significantly lower than 8-week-old mice after immunization of the two groups of cytokines and antibody isotype distribution is also different with the combination of MF59 results show that not infected with influenza virus in aged and young mice The immune response of the vaccine was significantly increased, in which the level of immune response in old mice was similar to that of the young mice immunized with the vaccine alone. Similarly, old mice previously infected with the influenza virus challenged the vaccine