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在22条开胸犬上观察了冠脉狭窄对血流量(CBF)的影响。用一可调节的微米缩窄器定量调节左旋支缩窄程度,测量了主动脉平均压(Pa)、冠脉远端小动脉平均压(Pc)和狭窄端压力降(ΔP)。冠脉狭窄程度与血流量变化曲线显示:在冠脉狭窄程度小于85％时,CBF相对稳定;随着狭窄程度的进一步增加,CBF急剧下降;而在狭窄程度大于95％后,CBF又缓慢下降。冠状动脉狭窄程度与CBF下降的曲线可用下列方程式表达: CBF=1.48×10~(10)e~(-27.6A)(A=冠脉狭窄程度) 冠脉狭窄程度大于50％时,狭窄程度与Pc呈负相关:Pc=159.1—1.36A(r=-0.73,P<0.01)。Pc与CBF呈正相关;Pc=16.9+1.3CBF(r=0.74,P<0.01)
The effects of coronary stenosis on blood flow (CBF) were observed in 22 open-chest dogs. The diameter of left circumflex artery was quantitatively adjusted by an adjustable micrometer constrictor, and mean arterial pressure (Pa), mean arterial pressure (Pc) and pressure drop (ΔP) were measured. The degree of coronary stenosis and blood flow curve showed that: CBF was relatively stable when the degree of coronary stenosis was less than 85%; CBF decreased sharply with the further increase of stenosis; CBF decreased slowly after the degree of stenosis was more than 95% . The curve of the degree of coronary artery stenosis and the decrease of CBF can be expressed by the following equation: CBF = 1.48 × 10-10 e -27.6A (A = degree of coronary artery stenosis) When the degree of coronary artery stenosis is more than 50%, the degree of stenosis is Pc was negatively correlated: Pc = 159.1-1.36A (r = -0.73, P <0.01). Pc was positively correlated with CBF; Pc = 16.9 + 1.3CBF (r = 0.74, P <0.01)