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目的检测细胞周期蛋白Cyclin D1和凋亡抑制因子Survivin在乳腺癌中的表达,探讨其与乳腺癌的关系。方法采用免疫组化法检测40例乳腺癌组织、40例乳腺纤维腺瘤组织以及20例正常乳腺组织中Cyclin D1和Survivin的表达,并分析其临床病理意义。结果Cyclin D1和Survivin在乳腺癌组织中的阳性表达率分别为72.5%(29/40)和65.0%(26/40),在乳腺纤维腺瘤中的阳性表达率分别为27.5%(11/40)和25.0%(10/40),而在正常乳腺组织中无表达,在乳腺癌中的表达明显高于乳腺良性肿瘤及正常乳腺组织(P<0.01);Cyclin D1和Survivin的阳性表达与乳腺癌的病期、有无淋巴结转移密切相关(P<0.05),而与肿瘤大小无关(P>0.05);Cyclin D1的阳性表达和Survivin的阳性表达呈正相关。结论Cyclin D1和Survivin在乳腺良、恶性肿瘤及乳腺正常组织中的表达有明显的差异;其表达与乳腺癌的病期及淋巴结转移有关;Cyclin D1和Survivin的表达有相关性。
Objective To detect the expression of Cyclin D1 and Survivin in breast cancer and to explore its relationship with breast cancer. Methods The expressions of Cyclin D1 and Survivin in 40 cases of breast cancer, 40 cases of breast fibroadenoma and 20 cases of normal breast tissues were detected by immunohistochemistry. The clinicopathological significance was also analyzed. Results The positive rates of Cyclin D1 and Survivin in breast cancer were 72.5% (29/40) and 65.0% (26/40), respectively. The positive rates of Cyclin D1 and Survivin in breast fibroadenoma were 27.5% (11/40) ) And 25.0% (10/40), respectively, but not in normal breast tissue (P <0.01). The positive expression rates of Cyclin D1 and Survivin were significantly higher in breast cancer than those in benign breast tumors and normal breast tissues (P <0.05), but not with tumor size (P> 0.05). The positive expression of Cyclin D1 was positively correlated with the positive expression of Survivin. Conclusion The expressions of Cyclin D1 and Survivin in breast benign and malignant tumors and normal breast tissues are significantly different. The expression of Cyclin D1 and Survivin is correlated with the stage of disease and lymph node metastasis. The expressions of Cyclin D1 and Survivin are correlated with each other.