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目的:比较急性冠脉综合征(ACS)患者与稳定型心绞痛及不同冠脉病变支数间血浆高敏C反应蛋白(HSCRP)水平差异以及阿托伐他汀的抗炎作用。方法:对经冠状动脉造影确诊的非冠心病74例、稳定性心绞痛32例、不稳定型心绞痛104例、急性心肌梗死25例采用颗粒增强的免疫透射比浊法测定HSCRP。对照ACS患者入院时和阿托伐他汀治疗1周后的HSCRP水平。结果:急性心肌梗死组、不稳定型心绞痛组均较对照组、稳定型心绞痛组显著增高,冠造无病变组较单支、双支、三支病变组血浆HSCRP显著低,但单支、双支、三支病变组之间差异无显著性。ACS患者经阿托伐他汀治疗1周后HSCRP显著下降。结论:ACS患者的血浆HSCRP水平明显升高,HSCRP可能是ACS的标志物。HSCRP水平与冠脉病变支数成无相关。阿托伐他汀具有抗炎作用。
Objective: To compare the differences of plasma high sensitive C-reactive protein (HSCRP) levels between patients with acute coronary syndrome (ACS) and stable angina and different coronary lesions and the anti-inflammatory effects of atorvastatin. Methods: 74 cases of non-coronary heart disease diagnosed by coronary angiography, 32 cases of stable angina pectoris, 104 cases of unstable angina pectoris and 25 cases of acute myocardial infarction were detected by particle-enhanced immuno-turbidimetry. HSCRP levels in control ACS patients at admission and atorvastatin treatment for 1 week. Results: Compared with control group and stable angina pectoris group, the plasma levels of HSCRP in patients with coronary heart disease were significantly lower than those without coronary heart disease Branch, three lesions was no significant difference between groups. HSCRP was significantly decreased in patients with ACS 1 month after atorvastatin treatment. Conclusion: Plasma HSCRP levels in patients with ACS are significantly higher than those in ACS patients. HSCRP may be a marker of ACS. HSCRP levels and coronary artery lesions into no correlation. Atorvastatin has an anti-inflammatory effect.