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Hedgehog(HH)信号通路是动物发育的关键调控之一~([1]),在所有的两侧对称动物中都有表达~([2]).HH信号通路有3种同源蛋白:SHH,IHH和DHH.Indian Hedgehog(IHH)信号通路是一条重要的发育相关通路,在多种生理过程中起非常关键的调控作用~([3]).在IHH基因敲除的小鼠(Mus musculus)模型中,IHH信号的缺失导致小鼠软骨内骨化发育过程中肢干缩短及各种
The Hedgehog (HH) signaling pathway is one of the key regulatory mechanisms in animal development, [1] and is expressed in all bilaterally symmetrical animals. [2] The HH signaling pathway has three homologous proteins: SHH , IHH and DHH. The Indian Hedgehog (IHH) signaling pathway is an important developmental pathway that plays a key regulatory role in a variety of physiological processes. [3]. In the IHH knockout mice (Mus musculus ) Model, the loss of IHH signal resulted in the shortening of limbs during the development of endochondral ossification and various