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目的:检测中国内蒙古汉族人群中MTHFR基因多态性与冠心病的关系。方法:研究组包括62例冠心病(coronaryheartdisease,CHD)患者和120例正常对照人群,用聚合酶链反应-限制性片段长度多态性技术(PCR-RFLP)分析C677T型突变。结果:677T/T基因型在冠心病人群中更普遍,是正常人群的3.4倍。结论:在内蒙古汉族人群中,677T/T基因型增加了个体患冠心病的风险性。
Objective: To investigate the relationship between MTHFR gene polymorphism and coronary heart disease in Han population of Inner Mongolia, China. Methods: The study group consisted of 62 patients with coronary heart disease (CHD) and 120 healthy controls. The C677T mutation was analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: The genotype of 677T / T was more common in patients with coronary heart disease, which was 3.4 times of normal population. Conclusion: 677T / T genotype increases the risk of coronary heart disease in the Han population of Inner Mongolia.