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目的:研究鼻内镜术后术腔愈合与鼻腔分泌液中血小板源性生长因子(PDGF)、肿瘤坏死因子α(TNF-α)、透明质酸(HA)的关系。方法:比较22例行鼻内镜术的患者术后第1~3阶段PDGF、TNF-α和HA间的差别;比较12周愈合良好者与愈合不良者之间手术前后PDGF、TNF-α和HA的差异性,以及性别、年龄、体重、分型分期方面的差异;并将术腔愈合情况与性别、年龄、体重、分型分期、术前3种因子含量之间行logistic回归分析。结果:①PDGF和HA在术后第1与第2、第1与第3阶段之间差异均有统计学意义,TNF-α在3个阶段之间差异无统计学意义。②鼻黏膜愈合情况与年龄、术前PDGF含量有关,年龄越小,PDGF含量越低,愈合越好,反之,愈合越差。结论:在鼻黏膜创伤愈合的不同阶段,PDGF、TNF-α和HA具有不同的分泌规律,年龄和术前PDGF含量是预测鼻黏膜愈合优劣的有效指标。
Objective: To study the relationship between postoperative nasal endoscopic healing and nasal secretion of platelet derived growth factor (PDGF), tumor necrosis factor alpha (TNF-alpha) and hyaluronic acid (HA). Methods: The differences of PDGF, TNF-α and HA between the first and third phases of 22 patients undergoing endoscopic sinus surgery were compared. The changes of PDGF, TNF-α and HA, and gender, age, body weight and staging. Logistic regression analysis was performed between the healing status of the cavity and gender, age, body weight, type and stage, and preoperative three factors. Results: ① There was significant difference between PDGF and HA in the first, the second, the first and the third stage after operation. There was no significant difference in TNF-α between the three stages. ② nasal mucosa healing and age, PDGF content before surgery, the younger, the lower the PDGF content, the better the healing, on the contrary, the worse the healing. CONCLUSIONS: Different stages of nasal mucosal wound healing, PDGF, TNF-α and HA have different secretion patterns, and age and preoperative PDGF content are effective indicators for predicting the quality of nasal mucosa healing.