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目的 探讨咪唑安定用于老年肿瘤病人在全麻诱导对循环功能的影响。方法 选择普胸手术 40例 ,按年龄分为老年组 ( 1组 ) 2 0例 ,中青年组 ( 2组 ) 2 0例。麻醉诱导时静注咪唑安定 0 2mg/kg ,观察诱导期间收缩压 (SBP)、舒张压 (DBP)、平均动脉压(MAP)、心率 (HR)的变化。结果 诱导后两组病人的SBP、DBP、MAP降低 ,1组更明显 (P <0 0 5 ) ,插管后两组SBP均回升 (P <0 0 5 ) ,2组的DBP、MAP有更明显的升高 (P <0 0 1)。整个诱导期间两组病例的HR变化不大。结论 咪唑安定麻醉效果强 ,起效快 ,适宜于全麻诱导 ,在老年病人诱导插管中能有效地抑制心血管反应 ,对老年病人可以安全地使用。
Objective To investigate the effect of midazolam on the circulatory function of elderly patients with cancer induction. Methods 40 cases of general thoracic surgery were selected. The patients were divided into two groups according to their age: the elderly group (group 1) and the middle-aged group (group 2). When anesthesia was induced, intravenous midazolam 0.2 mg/kg was administered intravenously to observe changes in systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), and heart rate (HR) during induction. Results After induction, SBP, DBP, and MAP decreased in both groups, and it was more obvious in group 1 (P < 0.05). After intubation, SBP increased in both groups (P <0 05). DBP and MAP in group 2 were even higher. Significant increase (P <0 01). There was little change in HR between the two groups throughout the induction period. Conclusion Midazolam has strong anesthetic effect, rapid onset, suitable for induction of general anesthesia, and can effectively inhibit cardiovascular reactions in elderly patients with intubation. It can be safely used for elderly patients.