Mutation Status of KRAS, BRAF, PIK3CA and Expression Level of AREG and EREG Identify Responders to C

• 作 者: Paulina Pechańska M. Becker T.
• 机 构: DRKKlinikenBerlin-K?penik,ExperimentalPharmacology&,OncologyBerlin-BuchGmbH,HELIOSKlinikumErfurt,
• 出 处: 癌症治疗(英文)
• 发表日期: 2013年2期
• 关键词: Colorectal Cancer XENOGRAFT MUTATION Biomarker CETUXIMAB Colorectal Cancer Xenog

To advance preclinical testing of novel targeted drugs in colorectal cancer (CRC) we established a panel of 133 mouse xenograft models from fresh tumor specimens of 239 patients with CRC of all four UICC stages. A subgroup of 67 xenograft models was treat