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目的探讨大黄的抗衰老效果和作用机理．方法３月龄昆明种健康雄性小鼠４０只，随机分为低剂量组、中剂量组、高剂量组、对照组，观察不同浓度的大黄水煎液对小鼠血中过氧化氢酶（ＣＡＴ）、超氧化物歧化酶（ＳＯＤ）、谷胱苷肽过氧化物酶（ＧＳＨ－Ｐｘ）活性及过氧化脂质（ＬＰＯ）含量的影响．结果大黄可增强小鼠血中ＳＯＤ、ＧＳＨ－Ｐｘ活性（Ｐ＜０．０５～０．０１），使ＬＰＯ含量降低（Ｐ＜０．０５～０．０１），其中尤以中、高剂量给药组作；用明显（Ｐ＜０．０１）．结论大黄可能具有延缓衰老的作用．中图分类号Ｒ２８）．Ｊ
Objective To explore the anti-aging effects and mechanism of rhubarb. Methods Forty healthy male mice of three months old Kunming were randomly divided into low-dose group, middle-dose group, high-dose group, and control group. The concentrations of rhubarb decoction in mice blood were measured for catalase (CAT). ), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) activity and lipid peroxide (LPO) content. Results Rhubarb could increase the activity of SOD and GSH-Px in the blood of the mice (P<0.05-0.01) and reduce the content of LPO (P<0.05-0.01), especially in the medium and high doses. Drug group; with obvious (P <0.01). Conclusion Rhubarb may have the effect of delaying aging. CLC number R28). J