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目的:观察纳络酮联合托烷司琼在预防醉酒饱胃患者急诊手术全麻时呕吐误吸的可行性.方法:60例醉酒饱胃患者因外伤需行急诊手术,随机分为观察组和对照组,每组30例.观察组患者入手术室建立静脉通道后立即静脉注射纳洛酮0.4 mg和托烷司琼5 mg;两组患者全麻前面罩吸氧10 min以上;准备好药品和抢救物品后,快速诱导无正压通气下行气管插管全身麻醉.观察麻醉诱导和术后清醒拔管呕吐误吸情况.结果:全麻诱导时两组均无呕吐,拔管时未用纳洛酮和托烷司琼组(对照组)有3例发生呕吐,1例轻微误吸,明显高于观察组,差异具有统计学意义(P<0.05).结论:醉酒饱胃患者全麻前用纳洛酮和托烷司琼对预防呕吐误吸有一定效果.“,”Objective: To observe the effects of prevention of vomiting and aspiration on drunk-full stomach in emergency patients general anesthesia. Methods: 60 drunk-full stomach patients of emergency operation were divided into two groups with 30 cases in each. Patients in the observation group were intravenously given naloxone (0.4 mg) and tropisetron (5 mg) after entering the operation room. Patients in both two groups spontaneously inhaled 100% oxygen via face mask more than10 min before induction of anesthesia.After preparation of drugs andrescue articles,all patients were intubated general anesthesia without positive pressure ventilation after induction of anesthesia. Then observed vomiting and aspiration during induction and after extubation. Results: There was no vomiting in the two groups during induction.The control group had 3 cases of vomiting,1 slight aspiration and more than observation group (P<0.05). Conclusion:Naloxone combined tropisetron have positive effects on the prevention of vomiting and aspiration to drunk-full stomach before general anesthesia.