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4例系统性硬皮病和1例泛发性硬斑病患者用环孢菌素(CS)治疗。定期随访血压,脉博,AKP,GOT,GPT,γ-GT,胆红素,尿常规,肌酐,肌酐清除率,尿酸,电解质,血细胞计数与分类和电泳。口服CS每日2次,剂量为2.2～5.6mg/kg/d,根据放射免疫测定调整血浓度维持在150～600ng/ml,治疗3～26个月。4例系统性硬皮病均有食道受累,3例有关节症状,心肺受累各2例,1例有肌炎。既往治疗曾用过强的松、青霉素、己酮可可碱、γ-干扰素、硝苯吡啶、乙酰水杨酸等。泛发性硬斑病患
Four patients with systemic scleroderma and one patient with Essential Hard Spot disease were treated with cyclosporine (CS). Regular follow-up of blood pressure, pulse, AKP, GOT, GPT, γ-GT, bilirubin, urine routine, creatinine, creatinine clearance, uric acid, electrolytes, blood cell count and electrophoresis. Oral CS 2 times a day, a dose of 2.2 ~ 5.6mg / kg / d, according to radioimmunoassay adjusted blood concentration was maintained at 150 ~ 600ng / ml for 3 to 26 months. 4 cases of systemic scleroderma had esophageal involvement, 3 cases of joint symptoms, cardiopulmonary involvement in 2 cases, 1 case of myositis. Previous treatment had been used prednisone, penicillin, pentoxifylline, γ-interferon, nifedipine, acetylsalicylic acid and so on. Panicularis disease