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目的:为阐明癌基因蛋白异常表达与HBV复制的关系.方法:用LSAB免疫组化和ELISA方法,检测了64例慢性HBV感染者肝细胞 C-erbB-2 P185、rasP~21、P~53癌基因蛋白和血清HBeAg_o结果:结果显示:C-erbB-2 P185和ras P~21阳性组血清HBeAg检出率分别为89.4%和84.6%,C-erbB-2P185、ras P~21阴性组 HBeAg检出率为20%和48%,两组差异显著.结论:表明癌基因蛋白c-erbB-2 P185和ras P~21的异常表达与 HBV复制密切相关.
Objective: To elucidate the relationship between abnormal expression of oncogene protein and HBV replication.Methods: The expression of C-erbB-2 P185, rasP-21 and P-53 in hepatocytes of 64 patients with chronic HBV infection were detected by LSAB immunohistochemistry and ELISA The results showed that the positive rate of HBeAg in C-erbB-2 P185 and ras P-21 positive group was 89.4% and 84.6%, respectively. The positive rate of HBeAg in C-erbB-2P185 and ras P-21 negative group The detection rates were 20% and 48%, respectively, with significant difference between the two groups.Conclusions: The abnormal expression of oncogene c-erbB-2 P185 and ras P-21 is closely related to HBV replication.