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目的 研究大鼠脊髓水平 M受体拮抗剂阿托品、哌仑西平对α2 受体激动剂可乐定抗伤害效应的影响。方法 SD大鼠蛛网膜下腔埋入导管并长期留置。实验时分别将生理盐水、可乐定、阿托品、阿托品 +可乐定、哌仑西平、哌仑西平 +可乐定经导管注入蛛网膜下腔 ,以热水甩尾阈值为痛反应指标 ,观察注药前后的效果。结果 可乐定可产生量效、时效相关的抗伤害反应 ;注射阿托品后3 0～ 90分钟和注射哌仑西平后 60～ 15 0分钟使甩尾阈值缩短 ;预注阿托品和预注哌仑西平可部分拮抗可乐定所产生的抗伤害效应。结论 在脊髓水平 ,α2 受体与脊髓内 M受体相关。
Objective To investigate the effects of atropine and pirenzepine, an antagonist of the M receptor antagonist, on the antinociceptive effects of clonidine, an α2 receptor agonist, at spinal level in rats. Methods SD rats were submarine submerged into the catheter and long-term indwelling. During the experiment, physiological saline, clonidine, atropine, atropine + clonidine, pirenzepine and pirenzepine + clonidine were respectively injected into the subarachnoid space through the catheter, the threshold of hot water flicking was taken as pain reaction index, Effect. Results Clonidine produced a dose-response and time-dependent anti-nociceptive response. The thrombus threshold was shortened from 30 to 30 minutes after injection of atropine and from 60 to 150 minutes after the injection of pirenzepine. Prednisolone and pirenoxib Partial antagonism of clonidine produced by the anti-injury effect. Conclusions At the spinal cord level, α2 receptors are associated with M receptors in the spinal cord.