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北京师范大学邱小波教授的研究团队发现,在精子发生和体细胞DNA损伤修复过程中,组蛋白均会降解。并且该团队还发现乙酰化,而不是泛素化,介导了组蛋白通过特异的蛋白酶体降解。泛素化和乙酰化分别为两种不同的蛋白修饰,在基因表达的表观遗传调控中都起着重要的作用。如泛素化一样,乙酰化不仅修饰组蛋白,还可以修饰众多其它蛋白。目前已在7000多种人类蛋白中发现2万多个乙酰化位点。这一发现
Professor Qiu Xiaobo from Beijing Normal University’s research team found that histone degrades during the process of spermatogenesis and somatic DNA damage repair. And the team also found that acetylation, rather than ubiquitination, mediated histone degradation through specific proteasomes. Ubiquitination and acetylation are two different protein modifications, respectively, which play an important role in epigenetic regulation of gene expression. Like ubiquitination, acetylation not only modifies histones, but also many other proteins. More than 20,000 acetylation sites have been found in over 7000 human proteins. This discovery