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目的观察莫西沙星对慢性阻塞性肺疾病急性发作动物模型气管内置管表面流感嗜血菌生物膜的影响。方法气管内注入流感嗜血菌建立慢性阻塞性肺疾病急性发作的动物模型,然后气管内置入硅胶管,观察莫西沙星是否对气管内置管表面流感嗜血菌生物膜的形成和膜内菌落计数产生影响。结果莫西沙星对气管内放置的硅胶管表面形成的生物膜有抑制作用,表现为用药后硅胶管表面分离的细菌数较少(P<0.05),扫描电镜也发现在莫西沙星作用下硅胶管表面无法形成成熟的生物膜,仅见散在的细菌黏附于管壁上,个别有细菌的散在团状聚集,但尚未融合呈膜状。结论莫西沙星是对气管内置管表面流感嗜血菌生物膜形成有抑制作用的抗菌药物。
Objective To investigate the effect of moxifloxacin on the biofilm of H. influenzae on the endotracheal tube of an acute episode of chronic obstructive pulmonary disease. Methods The model of acute episode of chronic obstructive pulmonary disease was established by intratracheal instillation of Haemophilus influenzae. Then the trachea was placed in a silicone tube to observe whether the moxifloxacin caused the formation of H. influenzae biofilm and the intracellular membrane count Have an impact. Results Moxifloxacin inhibited the biofilm formation on the surface of the silicone tube placed in the trachea. The results showed that the number of bacteria isolated on the surface of the silicone tube after administration was small (P <0.05), and the scanning electron microscopy also found that under the action of moxifloxacin, Tube surface can not form a mature biofilm, only scattered bacteria adhere to the tube wall, some bacteria scattered clusters gathered, but not yet fusion was membranous. Conclusion Moxifloxacin is an antibacterial agent that inhibits the formation of hemophilus influenzae on the surface of tracheal tube.