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对42例乙型菜场炎病毒(HBV)阳性,32例抗丙型肝炎病毒(HCV)抗体阳性及22例抗HCV与HBV双阳性原发性肝癌(PHC)病人外周血自然杀伤细胞(NK)活性及可溶性白细胞介素2受体(sIL-2R)水平进行了研究。结果发现,与正常人比,HBV阳性、抗HCV阳性及HBV与抗HCV双阳性PHC病人的NK活性均明显下降,sIL-2R水平均显著升高,二者呈明显负相关,且HBV阳性及HBV与抗HCV双阳性病人的sIL-2R水平明显高于抗HCV阳性病人,同时,ALT异常PHC病人的sIL-2R水平还明显高于ALT正常者。提示在PHC病人中sI1-2R的分泌不仅反映了HBV与HCV介导的细胞免疫是抑制状态,而且可为临床应用生物学反应调节治疗提供参考。
42 cases of hepatitis B virus (HBV) positive, 32 cases of anti-hepatitis C virus (HCV) antibody positive and 22 cases of anti-HCV and HBV double positive hepatocellular carcinoma (PHC) patients peripheral blood natural killer cells (NK) Active and soluble interleukin 2 receptor (sIL-2R) levels were studied. The results showed that compared with normal subjects, HBV positive, anti-HCV positive and NK activity in HBV and anti-HCV dual positive PHC patients were significantly decreased, sIL-2R levels were significantly increased, there was a significant negative correlation between the two, and HBV positive and The levels of sIL-2R in HBV and anti-HCV positive patients were significantly higher than those in patients with anti-HCV positive. At the same time, the sIL-2R levels in patients with abnormal ALT of ALT were significantly higher than those with normal ALT. It is suggested that the secretion of sI1-2R in PHC patients not only reflects the inhibition of HBV and HCV-mediated cellular immunity, but also provides reference for the clinical application of biological response modulation therapy.