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目的:观察原发性甲状腺机能减退症(甲减)患者激素替代治疗前后血脂及心肌酶学的变化。方法:76例甲减患者治疗前和治疗12周后分别测定空腹血清游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(sTSH)、总胆固醇(TC)、甘油三酯(TG)、肌酸磷酸激酶(CK)及同工酶(CKMB)。结果:治疗前TC、TG、CK、CKMB较对照组升高(P<0.01或P<0.05);治疗后上述指标均恢复至正常。结论:甲减与脂代谢、心肌酶学异常关系密切。
Objective: To observe the changes of lipids and myocardial enzymes in patients with primary hypothyroidism (Hypothyroidism) before and after hormone replacement therapy. Methods: The levels of free triiodothyronine (FT3), free thyroxine (FT4), thyrotropin (sTSH), total cholesterol (TC), glycerol Triester (TG), creatine phosphokinase (CK) and isoenzyme (CKMB). Results: The levels of TC, TG, CK and CKMB before treatment were higher than those of the control group (P <0.01 or P <0.05). After treatment, the above indexes returned to normal. Conclusion: Hypothyroidism and lipid metabolism, myocardial enzyme abnormalities are closely related.