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目的观察临床不稳定型心绞痛(UAP)病人血清抵抗素水平的变化及其临床意义。方法选取UAP病人28例,正常对照组30例。所有研究对象均测定血压、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高敏C-反应蛋白(hs-CRP)和抵抗素。结果UAP组患者的血压、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、hs-CRP和抵抗素水平与正常对照组比较均有明显升高(P<0.05),且UAP患者的抵抗素与hs-CRP有良好的正相关性(r=0.331,P<0.01)。结论抵抗素可能在UAP的发病中起着重要的作用,可以作为临床UAP识别和判断的重要指标。
Objective To observe the changes of serum resistin in patients with unstable angina pectoris (UAP) and its clinical significance. Methods 28 cases of UAP patients and 30 cases of normal control group were selected. All subjects measured blood pressure, triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high-sensitivity C-reactive protein (hs-CRP) and resistin. Results The blood pressure, triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), hs-CRP and resistin in UAP group were significantly higher than those in normal control group <0.05), and there was a positive correlation between resistin and hs-CRP in patients with UAP (r = 0.331, P <0.01). Conclusion Resistin may play an important role in the pathogenesis of UAP and can be used as an important index for clinical UAP identification and judgment.