【摘 要】
：
Non-small cell lung cancer is recognized as the deadliest cancer across the globe.In some areas,it is more common in women than even breast and cervical cancer.Its rise,vaulted by smoking habits and increasing air pollution,has garnered much attention and
【机 构】
：
Otogenetics Corp.,Atlanta,GA 30360,USA;Quest Diagnostics,San Juan Capistrano,CA 92675,USA;The Univer
论文部分内容阅读
Non-small cell lung cancer is recognized as the deadliest cancer across the globe.In some areas,it is more common in women than even breast and cervical cancer.Its rise,vaulted by smoking habits and increasing air pollution,has garnered much attention and resource in the medical field.The first lung cancer treatments were developed more than half a century ago.Unfortunately,many of the earlier chemotherapies often did more harm than good,especially when they were used to treat geneti-cally unsuitable patients.With the introduction of personalized medicine,physicians are increasingly aware of when,how,and in whom,to use certain anti-cancer agents.Drugs such as tyrosine kinase in-hibitors,anaplastic lymphoma kinase inhibitors,and monoclonal antibodies possess limited utility because they target specific oncogenic mutations,but other drugs that target mechanisms universal to all cancers do not.In this review,we discuss many of these non-oncogene-targeting anti-cancer agents including DNA replication inhibitors(i.e.,alkylating agents and topoisomerase inhibitors)and cytoskel-etal function inhibitors to highlight their application in the setting of personalized medicine as well as their limitations and resistance factors.
其他文献
The use of small interfering RNAs(siRNAs)has been under investigation for the treatment of several unmet medical needs,including acute lung injury/acute respiratory distress syndrome(ALI/ARDS)wherein siRNA may be implemented to modify the expression of pr
目的 了解天水市人类免疫缺陷病毒(human immunodeficiency virus,HIV)感染者和艾滋病(acquired immunodeficiency syndrome,AIDS)患者的生存时间及其影响因素.方法 利用中国疾病预防控制信息系统1997-2018年天水市艾滋病病例资料,采用回顾性队列研究的方法,用寿命表法计算生存率,用Cox比例风险回归模型分析生存时间的影响因素.结果 1016例HIV感染者/AIDS患者中,平均生存时间为152.69 (95％CI:145.51～159.88
Artificial intelligence(AI)is a general term that refers to the use of a machine to imitate intelligent behavior for performing complex tasks with minimal human intervention,such as machine learning;this technology is revolutionizing and reshaping medicin
伞蜥是飞蜥科爬行动物,体长0.6～1米,体重0.5～1千克.伞蜥的明显特征是其颈部周围的鳞状皱褶,在伞蜥被激怒或求偶时,这些皱褶会张开成一把伞的形状.伞蜥分布在大洋洲,主要以昆虫为食.
目的 分析2019-2021年北京市顺义区腺病毒引起的流感样病例暴发疫情,为学校腺病毒疫情防控工作提供参考.方法 收集2019-2021年北京市顺义区学校流感样病例暴发疫情资料,采用描述性流行病学方法分析3起腺病毒暴发疫情的流行特征,并与同期9起流感暴发疫情的临床症状和流行强度进行比较.结果 3起腺病毒暴发疫情共造成46人发病,总罹患率为1.80％ (46/2560).3起腺病毒暴发疫情均发生在冬季,腺病毒感染病例除发热外,症状以咽痛(30.43％)为主.腺病毒病例中的咳嗽、流涕、乏力报告率低于流感病例,
RAS,a member of the small GTPase family,functions as a binary switch by shifting between inactive GDP-loaded and active GTP-loaded state.RAS gain-of-function mutations are one of the leading causes in human oncogenesis,accounting for～19％of the global canc
The field of two-dimensional(2D)nanomaterial-based cancer immunotherapy combines research from multiple subdisciplines of material science,nano-chemistry,in particular nano-biological interactions,immunology,and medicinal chemistry.Most importantly,the“bi
Inhibitor of nuclear factor kappa-B kinase subunit beta(IKKβ)is one of important kinases in inflammation to phosphorylate inhibitor of nuclear factor kappa-B(IκBα)and then activate nuclear factor kappa-B(NF-κB).Inhibition of IKKβ has been a therapeutic st
Receptor activity-modulating proteins(RAMPs)are accessory molecules that form com-plexes with specific G protein-coupled receptors(GPCRs)and modulate their functions.It is established that RAMP interacts with the glucagon receptor family of GPCRs but the
目的 了解山东省东营市2010-2019年新报告人类免疫缺陷病毒(human immunodeficiency virus,HIV)感染者和艾滋病(acquired immunodeficiency syndrome,AIDS)患者的流行病学特点,为进一步制定有效的防控策略提供依据.方法 从“艾滋病综合防治信息系统”中,下载2010-2019年东营市HIV感染者/AIDS患者历史卡片库,采用描述性流行病学方法和x2检验对数据进行统计分析.结果 东营市2010-2019年新报告HIV感染者/AIDS患者共4