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自 1993年Ａｌｔｏｎｅｎ等首次发现在遗传性非息肉病性大肠癌细胞中存在高频率的微卫星不稳定性后 ,对微卫星不稳定性的研究已成为肿瘤基因研究新的热点之一。近期研究发现 ,微卫星 (ｍｉｃｒｏｓａｔｅｌｌｉｔｅ)及其不稳定性 (ｉｎｓｔａｂｉｌｉｔｙ)与大肠肿瘤发生和临床
Since Altonen et al. First discovered the high frequency of microsatellite instability in hereditary nonpolyposis colorectal cancer cells in 1993, the study of microsatellite instability has become one of the hot topics in tumor gene research. Recent studies have found that microsatellite and its instability are associated with the development of colorectal tumors and clinical